Cyclosporin A New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06979CAS No. ：59865-13-3Purity：98%

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Chemical Properties&Biological Activity

CAS No.	59865-13-3	Cat. No.	BCP06979
Name	Cyclosporin A
Synonyms	Cyclosporine; Ciclosporin;
SMILES
Chemical Name
Formula	C62H111N11O12	M. Wt	1202.61
Purity	98%	Storage	Store at 4-8°C
Description	Cyclosporin A binds to the cyclophilin (immunophilin) in T cells, forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM.

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