AZD 5438
Data Sheet
For research use only. Not for human use.
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| CAS No. | 602306-29-6 | Cat. No. | BCP02271 |
| Name | AZD 5438 | ||
| Synonyms | AZD-5438;AZD5438; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H21N5O2S | M. Wt | 371.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD5438 exhibits the potent inhibitory effect on activity of cyclin-dependent kinases including cyclin E-cdk2, cyclin A-cdk2, cyclin B1-cdk1, cyclin D3-cdk6, and cyclin T-cdk9 with IC50 of 6 nM, 45 nM, 16 nM, 21 nM, and 20 nM, respectively. Besides, AZD5438 also inhibits the kinase activity of p25-cdk5 and glycogen synthase kinase 3β with IC50 of 14 nM and 17 nM, respectively.AZD5438 induces cell cycle arrest by inhibiting phosphorylation of cdk-dependent substrates, and exhibits the broad antiproliferative activity against a range of tumor cell lines including lung, colorectal, breast, prostate, and hematologic tumors with IC50 ranging from 0.2 μM (MCF-7) to 1.7 μM (ARH-77). | ||
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