Home   >   Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-
Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- Chemical Structure

Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP11149CAS No. ：603-98-5Purity：98%
chem_1Get Quotation Now
 Tel: 0086-17754423994   or   orders@biochempartner.com
Real-Time Inquiry ×

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Inquiry Online ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
Bulk Inquiry ×

* Required Fields.

Please complete the form below and we will contact you shortly.

Product name

  

* Applicant name

Catalog Number

  

* Institution/Company

* Email address

  

Phone number

Country

  

* Quantity Required

Remarks
Submit
  • Chemical Properties&Biological Activity
CAS No. 603-98-5 Cat. No. BCP11149
Name Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)-
Synonyms 21-Deoxyhydrocortisone;11α,17α-Dihydroxy-4-pregnene-3,20-dione; 11α,17α-Dihydroxyprogesterone;11α,17-Dihydroxyprogesterone; (11α)-11,17-Dihydroxypregn-4-ene-3,20-dione;
SMILES CC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)O
Chemical Name
Formula C21H30O4 M. Wt 346.46
Purity 98% Storage Store at 4-8°C
Description Plasma 21-deoxycortisol (21DF) is an excellent marker of 21-hydroxylase deficiency. Currently, it is the only marker able to detect heterozygous carriers with 21-hydroxylase deficiency after Adrenocorticotropic Hormone (ACTH) stimulation. The syndrome of congenital adrenal hyperplasia (CAH) comprises the spectrum of autosomal recessive enzymatic disorders that impair cortisol biosynthesis. The hormonal pattern and clinical manifestations result from hyperstimulation of the adrenal cortex by excessive production of ACTH, untied from the negative feedback exerted by reduced cortisol levels, and the ultimate accumulation of F precursors and androgens. These abnormalities predispose the female newborn to ambiguous genitalia (female pseudohermaphroditism) and precocious puberty that may occur in both sexes. CAH due to 21-hydroxylase deficiency (21OHD) comprises nearly 90% of all cases, with an estimated worldwide incidence of 1 in 14, 000 live births. Because 21-deoxycortisol (21DF) is an 11b-hydroxylase (11bOH) derivative of 17-hydroxyprogesterone (17OHP), its serum levels are parallel and proportionally elevated in patients with 21OHD but decreased or undetectable in those with 11b-hydroxylase deficiency (11bOHD), another genetic disorder. Due to the marked buildup of 17OHP in 21OHD, this precursor steroid can proceed directly to 11-hydroxylation, producing distinct elevations of 21DF
  • Quality Control&Technical Support
In the process of purchasing and using Biochempartner products, you can consult us if you have any problems: orders@biochempartner.com. We will try our best to solve all your doubts.

Recommend Products

More >

Tags:Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- supplier,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- purchase,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- manufacturer,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- distributor,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- cost,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- buy,Pregn-4-ene-3,20-dione,11,17-dihydroxy-, (11a)- for sale

0086-13720134139