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Apremilast Chemical Structure

Apremilast

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP03783CAS No. ：608141-41-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 608141-41-9 Cat. No. BCP03783
Name Apremilast
Synonyms CC 10004;CC10004;CC-10004;
SMILES
Chemical Name
Formula C22H24N2O7S M. Wt 460.5
Purity 98% Storage Store at 4-8°C
Description Apremilast is more potent for inhibition of PDE4 compared with cAMP or cGMP hydrolysing enzymes from other PDE families. Apremilast displays a broad pattern of anti-inflammatory activity in a variety of cell types, inhibits TNF-α, IL-12 and IL-23 production, as well as NK and keratinocyte responses. Apremilast is found to inhibit the zymosan-induced PMN production of IL-8 with IC50 of 94 nM. Apremilast inhibits fMLF-induced PMN CD18 and CD11b expression with IC50 of 390 nM and 74 nM, respectively, and inhibits fMLF-induced adhesion of PMN to HUVECs with IC50 of 150 nM. Apremilast inhibits keratinocyte TNF-αproduction, with no effect on keratinocyte cell viability as measured by intracellular ATP levels.
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