Dibucaine HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 61-12-1 | Cat. No. | BCP04769 |
| Name | Dibucaine HCl | ||
| Synonyms | Cinchocaine;Nupercainal; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H30ClN3O2 | M. Wt | 379.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Dibucaine is an amide local anesthetic. Dibucaine reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain. Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch. | ||
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