Akti-1/2
Data Sheet
For research use only. Not for human use.
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| CAS No. | 612847-09-3 | Cat. No. | BCP13210 |
| Name | Akti-1/2 | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C34H29N7O | M. Wt | 551.64 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | In a cell-based IPKA (C33A) assay, Akti-1/2 inhibits Akt1 and Akt2 with IC50 of 305 nM and 2086 nM, respectively. In HT29, MCF7, and A2780 cells, Akti-1/2 induces cell apoptosis by dramatically increasing caspase-3 activity. In liver cells, Akti-1/2 blocks insulin regulation of PEPCK, G6Pase expression, and FOXO1 activity. Akti-1/2 also strongly potentiates PAR-1-mediated platelet aggregation by blocking PKB. In HCC827, NCI-H522, NCI-1651, and PC-9 cells, Akti-1/2 inhibits cell growth with IC50 of 4.7 μM, 7.25 μM, and 9.5 μM, when in combination with gefitinib, Akti-1/2 causes enhanced inhibition of cell growth and apoptosis. | ||
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