lasmiditan hydrochloride
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 613677-28-4 | Cat. No. | BCP17274 |
| Name | lasmiditan hydrochloride | ||
| Synonyms | COL 144 hydrochloride;LY 573144 hydrochloride;COL-144 hydrochloride; LY-573144 hydrochloride;COL144 hydrochloride;LY573144 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H19ClF3N3O2 | M. Wt | 413.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: In vitro binding studies Lasmiditan showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor, compared with K(i) values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively, a selectivity ratio greater than 470-fold. Lasmiditan show higher selectivity for the 5-HT(1F) receptor relative to other 5-HT(1) receptor subtypes than the first generation 5-HT(1F) receptor agonist LY334370. Unlike the 5-HT(1B/1D) receptor agonist sumatriptan, lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 μM. in vivo: In two rodent models of migraine, oral administration of lasmiditan potently inhibited markers associated with electrical stimulation of the trigeminal ganglion (dural plasma protein extravasation, and induction of the immediate early gene c-Fos in the trigeminal nucleus caudalis). | ||
Recommend Products
More >
-
Pipamperone dihydrochloride
Cat. No.：BCP49191
No.：2448-68-2
Product Details -
NAS-181 methanesulfonate
Cat. No.：BCP49052
No.：205242-62-2
Product Details -
Opiranserin
Cat. No.：BCP48961
No.：1441000-45-8
Product Details -
-
Prucalopride hydrochloride
Cat. No.：BCP48408
No.：179474-80-7
Product Details -
-
(Z)-Thiothixene
Cat. No.：BCP48214
No.：3313-26-6
Product Details -
S14506 hydrochloride
Cat. No.：BCP48185
No.：286369-38-8
Product Details -
-
-
Imipramine Hydrochloride
Cat. No.：BCP46885
No.：113-52-0
Product Details -
Zacopride hydrochloride
Cat. No.：BCP46391
No.：101303-98-4
Product Details -
-
-
PF-4479745
Cat. No.：BCP45867
No.：1065110-43-1
Product Details -
PF-3246799 hydrochloride
Cat. No.：BCP45866
No.：1065114-52-4
Product Details -
-
DOI hydrochloride
Cat. No.：BCP25643
No.：42203-78-1
Product Details -
-
Temanogrel
Cat. No.：BCP24269
No.：887936-68-7
Product Details
Tags:lasmiditan hydrochloride supplier,lasmiditan hydrochloride purchase,lasmiditan hydrochloride manufacturer,lasmiditan hydrochloride distributor,lasmiditan hydrochloride cost,lasmiditan hydrochloride buy,lasmiditan hydrochloride for sale