TBPB
Data Sheet
For research use only. Not for human use.
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| CAS No. | 634616-95-8 | Cat. No. | BCP13406 |
| Name | TBPB | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H32N4O | M. Wt | 404.55 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: TBPB activates M(1) through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its unprecedented selectivity. Whole-cell patch-clamp recordings demonstrated that activation of M(1) by TBPB potentiates NMDA receptor currents in hippocampal pyramidal cells but does not alter excitatory or inhibitory synaptic transmission, responses thought to be mediated by M(2) and M(4). in vivo: TBPB was efficacious in models predictive of antipsychotic-like activity in rats at doses that did not produce catalepsy or peripheral adverse effects of other mAChR agonists. | ||
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