LY404039

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01817CAS No. ：635318-11-5Purity：98%

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CAS No.	635318-11-5	Cat. No.	BCP01817
Name	LY404039
Synonyms	LY 404039;LY-404039; LY-404,039; LY404,039; LY 404,039; Pomaglumetad;
SMILES
Chemical Name
Formula	C7H9NO6S	M. Wt	235.21
Purity	98%	Storage	Store at 4-8°C
Description	LY404039 exhibits low binding affinity to group III mGlu receptors including mGlu6, mGlu7 and mGlu8 with a Ki value more than 5 μM. LY404039 shows little affinity for ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. LY404039 potently inhibits forskolin-stimulated cAMP formation in cells expressing human mGlu2 and mGlu3 receptors. LY404039 suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced L-glutamate release in the prefrontal cortex. LY404039 could modulate glutamatergic activity in limbic and forebrain areas relevant to psychiatric disorders and may be devoid of negative side effects associated with current antipsychotics and anxiolytics.