VcMMAE New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP10554CAS No. ：646502-53-6Purity：98%

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CAS No.	646502-53-6	Cat. No.	BCP10554
Name	VcMMAE
Synonyms	MC-Val-Cit-PAB-MMAE;mc-vc-PAB-MMAE;Maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl-monomethyl auristatin E;
SMILES
Chemical Name
Formula	C68H105N11O15	M. Wt	1316.63
Purity	98%	Storage	Store at 4-8°C
Description	VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors.