BAY 61-3606 dihydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 648903-57-5 | Cat. No. | BCP24726 |
| Name | BAY 61-3606 dihydrochloride | ||
| Synonyms | BAY 61-3606 2HCl;BAY 613606; BAY613606; BAY-613606; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H20Cl2N6O3 | M. Wt | 463.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BAY 61-3606 is a potent (Ki = 7.5 nM) and selective inhibitor of Syk kinase. BAY 61-3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61-3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8.1 nM). B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes were also potently suppressed by BAY 61-3606. | ||
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