Brivanib alaninate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 649735-63-7 | Cat. No. | BCP01783 |
| Name | Brivanib alaninate | ||
| Synonyms | BMS-582664;BMS 582664;BMS582664; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H24FN5O4 | M. Wt | 441.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BMS-582664 inhibits VEGF-stimulated and FGF-stimulated proliferating of HUVECs with IC50 of 40 nM and 276 nM. BMS-582664 (2 μM) significantly inhibits VEGFR2, FGFR1, ERK1/2 and Akt phosphorylation in VEGF- and bFGF-stimulated SK-HEP1 cells and HepG-2 cells, while BMS-582664 alone has little effect on levels of phosphorylated ERK1/2, Akt, VEGFR2, and FGFR1 in nonstimulated cells. BMS-582664 inhibits CYP2C19, CYP3A4(BFC) and CYP3A4 (BzRes) with IC50 of 2.4 μM, 0.51 μM and 1.6 μM, respectively. BMS-582664 exhibits high solid state stability (only 0.3% degradation at 50℃ with desiccant over a period of 12 weeks) and acceptable solution state stability up to pH 6.5. | ||
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