Phentolamine mesylate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 65-28-1 | Cat. No. | BCP09845 |
| Name | Phentolamine mesylate | ||
| Synonyms | Regitine mesylate;Phentolamine methanesulfonate;Rogitine;Vasomax; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H23N3O4S | M. Wt | 377.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Phentolamine Mesylate is a alpha 1- and alpha 2-blocking agent. Phentolamine leads to an increase in FBM by preferentially antagonizing presynaptic alpha 2-adrenoreceptors over postsynaptic alpha 1-adrenoreceptors. This influence of phentolamine on FBM may be secondary to its effect on ECoG. Promotion of LV-ECoG by catecholamines is mediated via an alpha 1-independent mechanism. phentolamine increased catecholamine release by presynaptic alpha 2-blockade, thereby suppressing the autoinhibition of transmitter release. This excess of catecholamines causes a rise of oxygen consumption and vasodilation by beta-adrenergic stimulation. Under beta-blockade, this excess competitively counteracts the postsynaptic vascular alpha-blockade. The combination of pre- and postsynaptic effects invalidates the use of phentolamine in the assessment of alpha-adrenoceptor-mediated vasoconstrictor tone. | ||
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