Reversine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 656820-32-5 | Cat. No. | BCP07534 |
| Name | Reversine | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H27N7O | M. Wt | 393.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors. | ||
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