RSV604

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP19830CAS No. ：676128-63-5Purity：98%

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CAS No.	676128-63-5	Cat. No.	BCP19830
Name	RSV604
Synonyms	A-60444; RSV-604; A60444; RSV 604; A 60444;
SMILES
Chemical Name
Formula	C22H17FN4O2	M. Wt	388.40
Purity	98%	Storage	Store at 4-8°C
Description	RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease.