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TG100-115 Chemical Structure

TG100-115

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02358CAS No. ：677297-51-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 677297-51-7 Cat. No. BCP02358
Name TG100-115
Synonyms TG 100115;TG 100-115;
SMILES
Chemical Name
Formula C18H14N6O2 M. Wt 346.3
Purity 98% Storage Store at 4-8°C
Description In human umbilical vein endothelial cells (HUVECs), TG100-115 (up to 10 μM) has no effects on cell proliferation and VEGF-stimulated ERK phosphorylation. However, TG100-115 (10 μM) interrupts other VEGF signaling pathways, such as those that culminate in VE-cadherin phosphorylation. [1] In HUVECs, TG100-115 (10 μM) inhibits the VEGF-induced increase of total level of VE-cadherin. TG100-115 inhibits VEGF mediated phosphorylation of mTOR and p70S6 kinase, both of which are downstream of PI3K. TG100-115 (125 nM to 10 μM) also inhibits FGF-stimulated phosphorylation of Akt.
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H-NMR HPLC
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