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PX-478 Chemical Structure

PX-478

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP07320CAS No. ：685847-78-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 685847-78-3 Cat. No. BCP07320
Name PX-478
Synonyms PX 478; PX478;
SMILES
Chemical Name
Formula C13H18Cl2N2O3 M. Wt 321.2
Purity 98% Storage Store at 4-8°C
Description PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of
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