Doxofylline New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12155CAS No. ：69975-86-6Purity：98%

Get Quotation Now

Tel: 0086-17754423994 or orders@biochempartner.com

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS No.	69975-86-6	Cat. No.	BCP12155
Name	Doxofylline
Synonyms	Ansimar; ABC-12-3; ABC-1213; ALT-07; DO-309; ABC 12 3; ABC 1213; ALT 07; DO 309; ABC12; 3; ABC1213; ALT07; DO309;
SMILES	O=C(N1C)N(C)C2=C(N(CC3OCCO3)C=N2)C1=O
Chemical Name
Formula	C11H14N4O4	M. Wt	266.26
Purity	98%	Storage	Store at 4-8°C
Description	Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies. In contrast with other xanthine derivatives, doxofylline does not significantly bind to adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. Decreased affinity for adenosine receptors may account for the better safety profile of doxofylline compared to theophylline. Unlike theophylline, doxofylline does not affect calcium influx and does not antagonize the actions of calcium channel blockers which could explain reduced cardiac adverse reactions associated with the drug. The anti-asthmatic effects of doxophylline are mediated by other mechanisms, primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.