Vidofludimus New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 717824-30-1 | Cat. No. | BCP14555 |
| Name | Vidofludimus | ||
| Synonyms | 4SC 101; 4SC-101; 4SC101; SC12267; SC-12267; SC 12267; | ||
| SMILES | COC1=CC=CC(=C1)C2=CC(=C(C=C2)NC(=O)C3=C(CCC3)C(=O)O)F | ||
| Chemical Name | |||
| Formula | C20H18FNO4 | M. Wt | 355.36 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Vidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes. In vivo, oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC-101 may have potential for the treatment of intestinal inflammation. Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for the treatment of autoimmune diseases. | ||
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