AR231453

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP08600CAS No. ：733750-99-7Purity：98%

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CAS No.	733750-99-7	Cat. No.	BCP08600
Name	AR231453
Synonyms	AR 231453; AR-231453;
SMILES
Chemical Name
Formula	C21H24FN7O5S	M. Wt	505.52
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: The GPR119-specific agonist AR231453 significantly increased cAMP accumulation and insulin release in both HIT-T15 cells and rodent islets. In both cases, loss of GPR119 rendered AR231453 inactive. In GLUTag cells, a well-established model of intestinal L-cell function, the potent GPR119 agonist AR231453 stimulated cAMP accumulation and GLP-1 release. in vivo: AR231453 also enhanced glucose-dependent insulin release in vivo and improved oral glucose tolerance in wild-type mice but not in GPR119-deficient mice. Diabetic KK/A(y) mice were also highly responsive to AR231453. Orally active GPR119 agonists may offer significant promise as novel antihyperglycemic agents acting in a glucose-dependent fashion. When administered in mice, AR231453 increased active GLP-1 levels within 2 min after oral glucose delivery and substantially enhanced total glucose-dependent insulinotropic peptide levels. Blockade of GLP-1 receptor signaling with exendin(9-39) reduced the ability of AR231453 t