Doxazosin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12228CAS No. ：74191-85-8Purity：98%

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CAS No.	74191-85-8	Cat. No.	BCP12228
Name	Doxazosin
Synonyms	UK 33274;UK-33274;UK33274;
SMILES
Chemical Name
Formula	C24H29N5O8S	M. Wt	547.58
Purity	98%	Storage	Store at 4-8°C
Description	Doxazosin is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor. The inhibition of cholesterol synthesis by doxazosin may cause cells to compensate by upregulating the LDL receptor, thereby increasing the importation of lipoprotein cholesterol and reducing LDL cholesterol in the medium. Doxazosin monotherapy was effective in eight of 12 patients (66.7%), and combined therapy with a beta-blocker was effective in 11 of 12 patients (91.7%). The mean pulse rate remained constant throughout therapy. Adverse reactions were minor and transient and occurred in only three patients. Urinary and plasma catecholamine levels tended to decrease or remained unchanged during doxazosin therapy.