MMAF
Data Sheet
For research use only. Not for human use.
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| CAS No. | 745017-94-1 | Cat. No. | BCP09397 |
| Name | MMAF | ||
| Synonyms | Monomethylauristatin F; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C39H65N5O8 | M. Wt | 731.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism. | ||
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