Volasertib New
* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS No. | 755038-65-4 | Cat. No. | BCP02405 |
Name | Volasertib | ||
Synonyms | BI 6727;BI-6727;BI6727; | ||
SMILES | |||
Chemical Name | |||
Formula | C34H50N8O3 | M. Wt | 618.81 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Like BI2536, BI6727 is an ATP-competitive kinase inhibitor from the dihydropteridinone class of compounds. In addition to Plk1, BI6727 also potently inhibits two closely related kinases Plk2 and Plk3 with IC50 of 5 nM and 56 nM, respectively. BI6727 at concentrations up to 10 μM displays no inhibitory activity against a panel of >50 other kinases. BI6727 inhibits the proliferation of multiple cell lines derived from various cancer tissues, including HCT116, NCI-H460, BRO, GRANTA-519, HL-60, THP-1, and Raji cells with EC50 of 23 nM, 21 nM, 11 nM, 15 nM, 32 nM, 36 nM, and 37 nM, respectively. BI6727 treatment (100 nM) in NCI-H460 cells induces an accumulation of mitotic cells with monopolar spindles and positive staining for histone H3 phosphoserine 10, confirming that cells are arrested early in the M phase, followed by induction of apoptosis. Low nanomolar concentrations of BI6727 display potent inhibitory activity against neuroblastoma (NB) tumor-initiating cells (NB TIC) with EC50 of |
Recommend Products
More >-
Onvansertib fumarate
Cat. No.:BCP49273
No.:1263293-37-3
Product Details -
TC-S 7005
Cat. No.:BCP48202
No.:1082739-92-1
Product Details -
-
ON1231320
Cat. No.:BCP40722
No.:1312471-39-8
Product Details -
-
CFI-400437
Cat. No.:BCP29569
No.:1247000-76-5
Product Details -
TAK-960 hydrochloride
Cat. No.:BCP28992
No.:1137868-96-2
Product Details -
CFI-400945 fumarate
Cat. No.:BCP25931
No.:1616420-30-4
Product Details -
-
Mps1-in-2
Cat. No.:BCP19164
No.:1228817-38-6
Product Details -
Centrinone
Cat. No.:BCP17384
No.:1798871-30-3
Product Details -
-
SBE 13 hydrochloride
Cat. No.:BCP23836
No.:1052532-15-6
Product Details -
LFM-A13(Z)
Cat. No.:BCP12817
No.:244240-24-2
Product Details -
Onvansertib
Cat. No.:BCP28066
No.:1034616-18-6
Product Details -
-
-
-
-
Rigosertib
Cat. No.:BCP08296
No.:592542-59-1
Product Details
Tags:Volasertib supplier,Volasertib purchase,Volasertib manufacturer,Volasertib distributor,Volasertib cost,Volasertib buy,Volasertib for sale