Apoptosis Activator 2
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 79183-19-0 | Cat. No. | BCP06746 |
| Name | Apoptosis Activator 2 | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C15H9Cl2NO2 | M. Wt | 306.14 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Apoptosis Activator 2 (20 μM) at the reduced cyto c concentration increases the fraction of Apaf-1 in the apoptosome by 1.5-fold to 33%. Apoptosis Activator 2 increases the extent of caspase-3 activation at the reduced level of cyto c and caspase-3 activation by 4-fold. Apoptosis Activator 2 strongly indues caspase-3 activation, PARP cleavage, and DNA fragmentation, and finally killing cells with an IC50 of 4 μM. Apoptosis Activator 2 induces apoptosis of PBL, HUVEC, Jurkat, Molt-4, CCRF-CEM, BT-549, MDA-MB-468 and NCI-H23 with of IC50 of 50 μM, 43 μM, 4 μM, 6 μM, 9 μM, 20 μM, 44 μM and 35 μM. Apoptosis Activator 2 exerts a cytostatic effect on the majority of tumor cell lines tested, inhibiting cell growth by 50-100% at 10 μM in 40 of 48 cell lines tested. Apoptosis Activator 2 induces cell death by triggering apoptosome formation. The level of En1 expression does not have a significant influence on the survival rates of Ventral midbrain cultures for Apoptosis Activator 2 (-8.1 ± 6.0% | ||
Recommend Products
More >
-
Protosappanin A
Cat. No.：BCP29498
No.：102036-28-2
Product Details -
Ginsenoside Rh2
Cat. No.：BCP23574
No.：78214-33-2
Product Details -
-
Glycochenodeoxycholic acid sodium salt
Cat. No.：BCP17748
No.：16564-43-5
Product Details -
-
Bisdemethoxycurcumin
Cat. No.：BCP16492
No.：24939-16-0
Product Details -
-
Sanguinarine
Cat. No.：BCP13614
No.：2447-54-3
Product Details -
-
-
Demethoxycurcumin
Cat. No.：BCP28284
No.：22608-11-3
Product Details -
Columbianadin
Cat. No.：BCP28238
No.：5058-13-9
Product Details -
-
Trabectedin
Cat. No.：BCP09790
No.：114899-77-3
Product Details -
Meisoindigo
Cat. No.：BCP09096
No.：97207-47-1
Product Details -
-
Betulinic acid
Cat. No.：BCP08998
No.：472-15-1
Product Details -
-
4-Hydroxybenzyl alcohol
Cat. No.：BCP27109
No.：623-05-2
Product Details -
Bisdemethoxycurcumin
Cat. No.：BCP08115
No.：33171-05-0
Product Details
Tags:Apoptosis Activator 2 supplier,Apoptosis Activator 2 purchase,Apoptosis Activator 2 manufacturer,Apoptosis Activator 2 distributor,Apoptosis Activator 2 cost,Apoptosis Activator 2 buy,Apoptosis Activator 2 for sale