Cyclosporine
Data Sheet
For research use only. Not for human use.
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| CAS No. | 79217-60-0 | Cat. No. | BCP13723 |
| Name | Cyclosporine | ||
| Synonyms | Neoral; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C62H111N11O12 | M. Wt | 1202.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cyclosporine induces phenotypic changes, including invasiveness of non-transformed cells, by a cell-autonomous mechanism. Cyclosporine treatment of adenocarcinoma cells results in striking morphological alterations, including membrane ruffling and numerous pseudopodial protrusions, increased cell motility, and anchorage-independent (invasive) growth. Cyclosporine (cyclosporin A, CsA) has potent immunosuppressive properties, reflecting its ability to block the transcription of cytokine genes in activated T cells. Cyclosporine through formation of a complex with cyclophilin inhibits the phosphatase activity of calcineurin, which regulates nuclear translocation and subsequent activation of NFAT transcription factors. Cyclosporine also blocks the activation of JNK and p38 signaling pathways triggered by antigen recognition, making CsA a highly specific inhibitor of T cell activation. Cyclosporine-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism | ||
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