Cisapride

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13754CAS No. ：81098-60-4Purity：98%

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CAS No.	81098-60-4	Cat. No.	BCP13754
Name	Cisapride
Synonyms	R 51619;R-51619;R51619;((plusmn))-Cisapride;
SMILES
Chemical Name
Formula	C23H29ClFN3O4	M. Wt	465.95
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Cisapride showed higher inhibitory effects on a hERG current, as indicated by its IC50 of 9.4 × 10-9 M. cisapride on cloned Kv4.3 channels stably expressed in Chinese hamster ovary cells were investigated using the whole-cell patch-clamp technique. Cisapride inhibited Kv4.3 in a concentration-dependent manner with IC50 values of 9.8 uM . in vivo: Cisapride (1 mg/kg i.v.), when administered 10 min after the start of GR113808 infusion, did not stimulate either antral or colonic motor activity under treatment with GR113808. The enhanced antral or colonic motor activity induced by these drugs was antagonized by treatment with GR113808 in dogs. cisapride could not bring about more colitis damages through 5HT(4) receptors. Based on the present study further researches are required for investigating the exact roles of 5HT(4) receptors in the pathogenesis of ulcerative colitis.