ISX-9

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16038CAS No. ：832115-62-5Purity：98%

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CAS No.	832115-62-5	Cat. No.	BCP16038
Name	ISX-9
Synonyms	ISX9;ISX 9;Isoxazole 9;Isoxazole9;Isoxazole 9;
SMILES
Chemical Name
Formula	C11H10N2O2S	M. Wt	234.27
Purity	98%	Storage	Store at 4-8°C
Description	At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test. ISX-9 is a neurogenic agent. Isx-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. Isx-9 also improves hippocampal function, enhancing memory in the Morris water maze. Notably, Isx-9 enhances neurogenesis and memory without detectable increases in cellular or animal activity or vascularization. Isx-9 enhances hippocampal neurogenesis and memory in vivo, and its effects are reliant on Mef2, revealing a novel cell-intr