CID16020046

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP20242CAS No. ：834903-43-4Purity：98%

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CAS No.	834903-43-4	Cat. No.	BCP20242
Name	CID16020046
Synonyms	CID-16020046;CID 16020046;
SMILES
Chemical Name
Formula	C25H19N3O4	M. Wt	425.44
Purity	98%	Storage	Store at 4-8°C
Description	IC50 value: 0.15 uM [1] Target: GPR55 antagonist In yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation. In human embryonic kidney(HEK293) cells stably expressing human GPR55, the compound behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2.CID16020046 concentration dependently inhibited LPI-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor k of activated B cells (NF-kB) and serum response element, translocation of NFAT and NF-kB, and GPR55 internalization. It reduced LPI-induced wound healing in primary human lung microvascular endothelial cells and reversed LPI-inhibited platelet aggregation.