GNF 7

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP17217CAS No. ：839706-07-9Purity：98%

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CAS No.	839706-07-9	Cat. No.	BCP17217
Name	GNF 7
Synonyms	GNF-7;GNF7;
SMILES
Chemical Name
Formula	C28H24F3N7O2	M. Wt	547.53
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: GNF-7 is amongst the first type II inhibitors capable of inhibiting T315I to be described and will serve as a valuable lead to design next generation Bcr-Abl kinase inhibitors. GNF-7 exhibits some selectivity (4 to 100-fold) for T315I Bcr-Abl (IC50 = 11 nM, in Ba/F3 cell line) relative to kinases such as TPR-Met, NPM-ALK, JAK-3, Flt-3. in vivo: GNF-7 displays significant efficacy against T315I-Bcr-Abl without appreciable toxicity in a bioluminescent xenograft mouse model using a transformed T315I-Bcr-Abl-Ba/F3 cell line that has a stable luciferase expression. GNF-7 exhibits excellent pharmacokinetic parameters in mice, with good systemic exposure (AUC = 26656 hrs*nM, Cmax = 3.6 uM) along with reasonable half life (t1/2=3.2 hrs) and favorable oral bioavailability (BAV=36%) being observed following oral administration of a single dose of 20 mg/kg.