Lamotrigine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12156CAS No. ：84057-84-1Purity：98%

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CAS No.	84057-84-1	Cat. No.	BCP12156
Name	Lamotrigine
Synonyms	Lamictal;Epilepax;LTG;BW430C;
SMILES
Chemical Name
Formula	C9H7Cl2N5	M. Wt	256.09
Purity	98%	Storage	Store at 4-8°C
Description	Lamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate . In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected . Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels . Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed