Canagliflozin New
Data Sheet
For research use only. Not for human use.
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Publications Citing of Biochempartner's Canagliflozin
| CAS No. | 842133-18-0 | Cat. No. | BCP02520 |
| Name | Canagliflozin | ||
| Synonyms | JNJ 24831754; JNJ24831754; JNJ-24831754; JNJ24831754AAA; JNJ24831754ZAE; TA 7284; TA-7284; TA7284; | ||
| SMILES | CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F | ||
| Chemical Name | |||
| Formula | C24H25FO5S | M. Wt | 444.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 μM and >1 μM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 μM) or phlorizin (3 mM) alone in the presence of 50 μM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 μM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively. | ||
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