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ARRY-334543 Chemical Structure

ARRY-334543

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02574CAS No. :845272-21-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 845272-21-1 Cat. No. BCP02574
Name ARRY-334543
Synonyms ASLAN001; ASLAN-001; ASLAN 001; ARRY 334543;ARRY334543; ARRY543; ARRY-543; ARRY 543; Varlitinib;
SMILES
Chemical Name
Formula C22H19ClN6O2S M. Wt 466.94
Purity 98% Storage Store at 4-8°C
Description ARRY334543 behaves as a reversible ATP-competitive inhibitor with nanomolar potency (Ki=1 nM) both in vitro and in cell-based proliferation assays using A431 and BT-474 cells. ARRY334543 is an AKT pathway inhibitor in cells that contains active ErbB-2 receptors. ARRY334543 suppresses ErbB-2 and ErbB-1 phosphorylation in human cancer cells, such as BT-474 with IC50 of 43 nM) and A431 with IC50 of 36 nM) that overexpress ErbB-2 and ErbB-1, respectively.
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