ARRY-334543
Data Sheet
For research use only. Not for human use.
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| CAS No. | 845272-21-1 | Cat. No. | BCP02574 |
| Name | ARRY-334543 | ||
| Synonyms | ASLAN001; ASLAN-001; ASLAN 001; ARRY 334543;ARRY334543; ARRY543; ARRY-543; ARRY 543; Varlitinib; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H19ClN6O2S | M. Wt | 466.94 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ARRY334543 behaves as a reversible ATP-competitive inhibitor with nanomolar potency (Ki=1 nM) both in vitro and in cell-based proliferation assays using A431 and BT-474 cells. ARRY334543 is an AKT pathway inhibitor in cells that contains active ErbB-2 receptors. ARRY334543 suppresses ErbB-2 and ErbB-1 phosphorylation in human cancer cells, such as BT-474 with IC50 of 43 nM) and A431 with IC50 of 36 nM) that overexpress ErbB-2 and ErbB-1, respectively. | ||
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