Foretinib
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CAS No. | 849217-64-7 | Cat. No. | BCP02231 |
Name | Foretinib | ||
Synonyms | XL880;GSK1363089;GSK089;EXEL-2880;XL-880;GSK 1363089;GSK 089;EXEL2880;XL 880;GSK-1363089;GSK-089;EXEL2880; | ||
SMILES | |||
Chemical Name | |||
Formula | C34H34F2N4O6 | M. Wt | 632.67 |
Purity | 98% | Storage | Store at 4-8°C |
Description | XL880 inhibits HGF receptor family tyrosine kinases with IC50 values of 0.4 nM for Met and 3 nM for Ron. XL880 also inhibits KDR, Flt-1, and Flt-4 with IC50 values of 0.9 nM, 6.8 nM and 2.8 nM, respectively. XL880 inhibits colony growth of B16F10, A549 and HT29 cells with IC50 of 40 nM, 29 nM and 165 nM, respectively. A recent study indicates XL880 affects cell growth differently in gastric cancer cell lines MKN-45 and KATO-III. XL880 inhibits phosphorylation of MET and downstream signaling molecules in MKN-45 cells, while targets GFGR2 in KATO-III cells. |
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