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PR104 Chemical Structure

PR104

Data Sheet For research use only. Not for human use.
Cat. No. :BCP13137CAS No. :851627-62-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 851627-62-8 Cat. No. BCP13137
Name PR104
Synonyms PR-104;PR 104;
SMILES
Chemical Name
Formula C14H20BrN4O12PS M. Wt 579.27
Purity 98% Storage Store at 4-8°C
Description Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues.
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