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Bafetinib Chemical Structure

Bafetinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP22045CAS No. ：859212-16-1Purity：99%
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  • Chemical Properties&Biological Activity
CAS No. 859212-16-1 Cat. No. BCP22045
Name Bafetinib
Synonyms INNO406; INNO-406; INNO 406; NS187; NS-187; NS 187;
SMILES
Chemical Name
Formula C30H31F3N8O M. Wt 576.61
Purity 99% Storage Store at 4-8°C
Description Bafetinib, also known as INNO-406 and NS187, is an orally bioavailable 2-phenylaminopyrimidine derivative with potential antineoplastic activity. Bafetinib specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). This agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types.
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