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NVP-BAW2881 Chemical Structure

NVP-BAW2881

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP17232CAS No. ：861875-60-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 861875-60-7 Cat. No. BCP17232
Name NVP-BAW2881
Synonyms NVP BAW2881;NVPBAW2881;
SMILES
Chemical Name
Formula C22H15F3N4O2 M. Wt 424.38
Purity 98% Storage Store at 4-8°C
Description BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. NVP-BAW2881 inhibited proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. NVP-BAW2881 reduced the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalized the epidermal architecture. NVP-BAW2881 also displayed strong anti-inflammatory effects in models of acute inflammation; pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice.
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