AMG 837

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP14587CAS No. ：865231-46-5Purity：98%

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CAS No.	865231-46-5	Cat. No.	BCP14587
Name	AMG 837
Synonyms	AMG837;AMG 837;
SMILES
Chemical Name
Formula	C26H21F3O3	M. Wt	438.44
Purity	98%	Storage	Store at 4-8°C
Description	AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. AMG 837 is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. showed no significant activity in cell-based assays against PPARα, δ, and γ. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50 = 3 uM) on the a2-adrenergic receptor. Overall, AMG 837 was both highly potent and selective in vitro.