CX-3543
Data Sheet
For research use only. Not for human use.
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| CAS No. | 865311-47-3 | Cat. No. | BCP01793 |
| Name | CX-3543 | ||
| Synonyms | Quarfloxin;CX3543;CX 3543; Itarnafloxin; Quarfloxacin; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C35H33FN6O3 | M. Wt | 604.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CX-3543 is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis. | ||
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