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SN-38 Chemical Structure

SN-38

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01386CAS No. ：86639-52-3Purity：98.00%
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  • Chemical Properties&Biological Activity
CAS No. 86639-52-3 Cat. No. BCP01386
Name SN-38
Synonyms SN38; SN 38; NK 012;NK-012;NK012;7-Ethyl-10-hydroxycamptothecin;
SMILES O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C2)=O
Chemical Name
Formula C22H20N2O5 M. Wt 392.4
Purity 98.00% Storage Store at 4-8°C
Description SN-38, a biological active metabolite of irinotecan hydrochloride (CPT-11). SN-38 causes the strongest inhibition of DNA topoisomerase I, followed by CPT and then CPT-11. CPT-11 dose dependently shifts the position of relaxed DNA in the direction of nicked DNA, but SN-38 and CPT shows no effect on the position of relaxed DNA. SN-38 dose-dependently and time-dependently inhibit DNA synthesis. Respective IC50 values of SN-38, in DNA synthesis is 0.077 μM.
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H-NMR HPLC H-NMR LCMS
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