TG100572

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP18234CAS No. ：867334-05-2Purity：98%

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CAS No.	867334-05-2	Cat. No.	BCP18234
Name	TG100572
Synonyms	TG-100572;TG 100572;
SMILES
Chemical Name
Formula	C26H26ClN5O2	M. Wt	475.97
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: TG100572 inhibited vascular endothelial cell proliferation in vitro (ED50= 610 ± 71 nM, mean ± SEM, N= 3) and blocked VEGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), a signaling event in VEGF-induced mitogenesis. Additionally, TG100572 induced apoptosis in rapidly proliferating, but not quiescent, endothelial cell cultures . TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV-induced angiogenesis and significantly reduced the severity of SK lesions. in vivo: Mice that received daily intraperitoneal injections of TG100572 (5 mg/kg) developed smaller CNV lesions than those seen in vehicle-injected mice; measuring CNV area using image analysis techniques demonstrated a 40% reduction compared to the vehicle control group.TG100572-treated group also lost an average 11% of their body weight over the 14 day course of this study compared to the veh