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Apilimod dimesylate Chemical Structure

Apilimod dimesylate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP15711CAS No. :870087-36-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 870087-36-8 Cat. No. BCP15711
Name Apilimod dimesylate
Synonyms STA 5326 mesylate;STA-5326 mesylate;STA5326 mesylate; AIT-101 mesylate;
SMILES CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4.CS(=O)(=O)O.CS(=O)(=O)O
Chemical Name
Formula C25H34N6O8S2 M. Wt 610.7
Purity 98% Storage Store at 4-8°C
Description Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
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