Fevipiprant
Data Sheet
For research use only. Not for human use.
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| CAS No. | 872365-14-5 | Cat. No. | BCP25015 |
| Name | Fevipiprant | ||
| Synonyms | NVP-QAW039; NVP-QAW 039; NVP-QAW-039;QAW-039; QAW039; QAW 039; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H17F3N2O4S | M. Wt | 426.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment. [(3)H]-QAW039 displayed high affinity for the human CRTh2 receptor (1.14 ± 0.44 nM) expressed in Chinese hamster ovary cells, the binding being reversible and competitive with the native agonist prostaglandin D2(PGD2). QAW039 was also a potent inhibitor of PGD2-induced cytokine release in human Th2 cells. Fevipiprant reduces eosinophilic airway inflammation and is well tolerated in patients with persistent moderate-to-severe asthma and raised sputum eosinophil counts despite inhaled corticosteroid treatment. Fevipiprant demonstrates a favorable safety profile. | ||
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