Quisinostat 2HCl
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 5.00 mg | Get quote | In-stock | Quotation Inquiry |
| 25.00 mg | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 875320-31-3 | Cat. No. | BCP20792 |
| Name | Quisinostat 2HCl | ||
| Synonyms | JNJ26481585; JNJ-26481585; JNJ 26481585; JNJ-26481585-AAC; JNJ26854165 2HCl; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H28Cl2N6O2 | M. Wt | 467.40 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Potent, orally available second-generation pan-HDAC inhibitor (highest IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with activity in human leukemia. JNJ-26481585 induces continuous acetylation of histone H3, activation of the caspase cascade, and upregulation of p21, resulting in apoptosis and cell cycle arrest in the myeloma cells at low nanomolar concentrations. JNJ26481585 also potently induced tubulin acetylation. | ||
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