AZD5069

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP23519CAS No. ：878385-84-3Purity：98%

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CAS No.	878385-84-3	Cat. No.	BCP23519
Name	AZD5069
Synonyms	AZD-5069; AZD 5069;
SMILES	CC(C(CO)O)OC1=NC(=NC(=C1)NS(=O)(=O)N2CCC2)SCC3=C(C(=CC=C3)F)F
Chemical Name
Formula	C18H22F2N4O5S2	M. Wt	476.52
Purity	98%	Storage	Store at 4-8°C
Description	AZD-5069 is a potent and selective CXCR2 antagonist used for caner treatment. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Furthermore, AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1. AZD5069 was a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics. AZD-5069 is also potential useful for patient in inflammatory conditions.