DUP-697
Data Sheet
For research use only. Not for human use.
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| CAS No. | 88149-94-4 | Cat. No. | BCP12701 |
| Name | DUP-697 | ||
| Synonyms | DUP 697;DUP697; S-6907; S 6907; S6907; BFMT; | ||
| SMILES | O=S(C1=CC=C(C2=C(C3=CC=C(F)C=C3)SC(Br)=C2)C=C1)(C)=O | ||
| Chemical Name | |||
| Formula | C17H12BrFO2S2 | M. Wt | 411.31 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DuP-697, also known as S-6907 and BFMT, is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of rheumatoid arthritis (RA) and osteoarthritis. DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP-697 significantly suppressed K562 cells and primary CML cells growth and induced apoptosis in a concentration-dependent manner and the growth-inhibiting effect was independent on Philadelphia chromosome. DuP-697, at concentrations ranges which do not inhibit PGHS-1 activity, significantly attenuated the inhibition of PGHS-1 that was caused by aspirin and indomethacin. | ||
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