CCG50014
Data Sheet
For research use only. Not for human use.
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| CAS No. | 883050-24-6 | Cat. No. | BCP06015 |
| Name | CCG50014 | ||
| Synonyms | CCG 50014;CCG-50014; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H13FN2O2S | M. Wt | 316.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. | ||
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