GW9508
Data Sheet
For research use only. Not for human use.
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| CAS No. | 885101-89-3 | Cat. No. | BCP06803 |
| Name | GW9508 | ||
| Synonyms | GW 9508; GW-9508; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H21NO3 | M. Wt | 347.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GW9508 (10 - 40microM) did not influence basal insulin levels at 2mM glucose, but it (above 20 microM) significantly inhibited 5mM and 15mM glucose-stimulated insulin secretion. GW9508 is an agonist of G protein-coupled receptor 40 (GPR40) that is expressed in pancreatic beta-cells and was reported to regulate insulin secretion. GPR40 is a novel potential target for the treatment of type 2 diabetes. in vitro: Using small interfering ribonucleic acid to delete GPR40 in HepG2 cells, we demonstrate | ||
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