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Bafetinib Chemical Structure

Bafetinib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01377CAS No. ：887650-05-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 887650-05-7 Cat. No. BCP01377
Name Bafetinib
Synonyms INNO-406;INNO406;INNO 406;NS-187;NS 187;NS187;
SMILES
Chemical Name
Formula C30H31F3N8O M. Wt 576.62
Purity 98% Storage Store at 4-8°C
Description Bafetinib blocks WT Bcr-Abl autophosphorylation and its downstream kinase activity with IC50 of 11 nM and 22 nM in K562 and 293T cells, respectively. Bafetinib suppresses the growth of the Bcr-Abl-positive cell lines including K562, KU812, and BaF3/wt cells potently without effects on the proliferation of the Bcr-Abl-negative U937 cell line. Moreover, Bafetinib exhibits a dose-dependent antiproliferative effect against Bcr-Abl point mutant cell lines, such as BaF3/E255K cells. In Bcr-Abl+ leukemi
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H-NMR LCMS
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