Bafilomycin A1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 88899-55-2 | Cat. No. | BCP02104 |
| Name | Bafilomycin A1 | ||
| Synonyms | Baf-A1; NSC 381866; NSC-381866; NSC381866; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C35H58O9 | M. Wt | 622.83 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Bafilomycin A1 inhibits the short circuit current induced by the outer mantle epithelium (OME). The IC50 and maximum inhibition dose of Bafilomycin A1 are 0.17 μM and 0.5 μM, respectively. In addition, Bilomycin A1 inhibits the acid influx with an IC50 value of 0.4 nM. Bafilomycin A1 inhibits the acidification dose-dependently resulting in a lower quenching, and thus a higher fluorescence. Bafilomycin A1 prevents the vacuolization of Hela cells induced by H. pylori, with an inhibitory concentration giving 50% of maximal (ID50) of 4 nM. Bafilomycin A1 is also very efficient in restoring vacuolated cells to a normal appearance.Bafilomycin A1 also affects the transport of endocytosed material from early to late endocytic compartments. Bafilomycin not only dissipates the low endosomal pH but also blocks transport from early to late endosomes in HeLa cells.Bafilomycin A1 at doses of 0.1-1 μM completely inhibits the acidification of lysosomes revealed by the incubation with acridine orange i | ||
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