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Ceralifimod Chemical Structure

Ceralifimod

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20384CAS No. ：891859-12-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 891859-12-4 Cat. No. BCP20384
Name Ceralifimod
Synonyms UNII-BZ2O8A84A4;ONO-4641; ONO 4641; ONO4641;
SMILES CCCC1=CC=C(COC2=CC(CCC(CN3CC(C(O)=O)C3)=C4C)=C4C=C2)C(OC)=C1
Chemical Name
Formula C27H33NO4 M. Wt 435.56
Purity 98% Storage Store at 4-8°C
Description Ceralifimod, also known as ONO-4641, is a next-generation sphingosine 1-phosphate (S1P) receptor agonist selective for S1P receptors 1 and 5. In vitro, ONO-4641 showed highly potent agonistic activities versus S1P receptors 1 and 5 [half maximal effective concentration (EC(50) ) values of 0·0273 and 0·334 nM, respectively]. ONO-4641 decreased peripheral blood lymphocyte counts in rats by inhibiting lymphocyte egress from secondary lymphoid tissues. ONO-4641 prevented relapse of disease in a non-obese diabetic mouse model of relapsing-remitting EAE. ONO-4641 may provide therapeutic benefits in the treatment of multiple sclerosis.
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